SMPD2 antibody (N-Term)

Catalog No. ABIN2782209

There is 1 publication for this product available. The Rabbit Polyclonal anti-SMPD2 antibody is suitable to detect SMPD2 in samples from Human, Rat, Mouse, Dog, Cow, Horse, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for SMPD2 antibody (N-Term) (ABIN2782209)

Target: SMPD2 (Sphingomyelin phosphodiesterase 2, Neutral Membrane (Neutral Sphingomyelinase) (SMPD2))

Reactivity: Human, Rat, Mouse, Dog, Cow, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMPD2 Antibody

Binding Specificity: N-Term

Sequence: RQKLSPTYPA AHHFRSGIIG SGLCVFSKHP IQELTQHIYT LNGYPYMIHH

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 77%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SMPD2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMPD2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 423 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SMPD2 antibody (ABIN2782209)

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Target Details for SMPD2

Target: SMPD2 (Sphingomyelin phosphodiesterase 2, Neutral Membrane (Neutral Sphingomyelinase) (SMPD2))

Alternative Name: SMPD2

Background: SMPD2 converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
Alias Symbols: NSMASE, ISC1, NSMASE1
Protein Interaction Partner: UBC, PIK3CG,
Protein Size: 423

Molecular Weight: 48 kDa

Gene ID: 6610

NCBI Accession: NM_003080, NP_003071

UniProt: O60906

Pathways: Neurotrophin Signaling Pathway