TAPBP antibody (N-Term)

Catalog No. ABIN2782217

This anti-TAPBP antibody is a Rabbit Polyclonal antibody detecting TAPBP in WB and IHC. Suitable for Human, Mouse, Rat, Sheep, Pig, Horse, Dog and Rabbit.

Quick Overview for TAPBP antibody (N-Term) (ABIN2782217)

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Reactivity: Human, Mouse, Rat, Sheep, Pig, Horse, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAPBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TAPBP Antibody

Binding Specificity: N-Term

Sequence: GKGLAKRPGA LLLRQGPGEP PPRPDLDPEL YLSVHDPAGA LQAAFRRYPR

Predicted Reactivity: Dog: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 93%, Rat: 86%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against TAPBP. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TAPBP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 299 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TAPBP

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Alternative Name: TAPBP

Background: TAPBP is a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum.
Alias Symbols: NGS17, TAPA, TPN, TPSN
Protein Interaction Partner: UBC, PDIA3, Tap2, ELAVL1, US3, TAP1, B2M, COPG1, COPG2, COPB1, HLA-C, HLA-A, CALR,
Protein Size: 299

Molecular Weight: 30 kDa

Gene ID: 6892

NCBI Accession: NM_172208, NP_757345

UniProt: O15533