Liver Arginase antibody (N-Term)

Catalog No. ABIN2782309

This Rabbit Polyclonal antibody specifically detects Liver Arginase in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog, Pig, Horse, Goat and Saccharomyces cerevisiae.It has been mentioned in 1 publication

Quick Overview for Liver Arginase antibody (N-Term) (ABIN2782309)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog, Pig, Horse, Goat, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Liver Arginase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Liver Arginase Antibody

Binding Specificity: N-Term

Purpose: ARG1 Antibody - N-terminal region

Sequence: SAKSRTIGII GAPFSKGQPR GGVEEGPTVL RKAGLLEKLK EQECDVKDYG

Cross-Reactivity: Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%

Characteristics: This is a rabbit polyclonal antibody against ARG1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ARG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45671-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-Liver Arginase antibody (ABIN2782309)

Kitowska, Zakrzewicz, Königshoff, Chrobak, Grimminger, Seeger, Bulau, Eickelberg: "Functional role and species-specific contribution of arginases in pulmonary fibrosis." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 1, pp. L34-45, (2008) (PubMed).

Target Details for Liver Arginase

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Alternative Name: ARG1

Background:

Background Information: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Arginase, liver

Alternative Symbols: -

Protein Name: Arginase-1

Molecular Weight: 35kDa

Gene ID: 383

NCBI Accession: NP_000036

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin