KNG1 antibody (C-Term)

Catalog No. ABIN2782315

The Rabbit Polyclonal anti-KNG1 antibody (ABIN2782315) specifically detects KNG1 in WB. The antibody is reactive with Human samples.

Quick Overview for KNG1 antibody (C-Term) (ABIN2782315)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KNG1 Antibody

Binding Specificity: C-Term

Purpose: KNG1 Antibody - C-terminal region

Sequence: ISLMKRPPGF SPFRSSRIGE IKEETTSHLR SCEYKGRPPK AGAEPASERE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against KNG1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human KNG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45681-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: KNG1

Background:

Background Information: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

Gene Name: kininogen 1

Alternative Symbols: BK, BDK, KNG, HMWK

Protein Name: kininogen-1

Molecular Weight: 32kDa

Gene ID: 3827

NCBI Accession: NP_000884

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process