SIK1 antibody (Middle Region)

Catalog No. ABIN2782412

Product Details anti-SIK1 Antibody

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Dog, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIK1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TPVLQSQAGL GATVLPPVSF QEGRRASDTS LTQGLKAFRQ QLRKNARTKG

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against Sik1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 776 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SIK1 antibody (ABIN2782412)

McTague, Ferguson, Chik, Ho: "The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte." in: Molecular and cellular endocrinology, Vol. 414, pp. 156-67, (2015) (PubMed).

Target Details for SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Alternative Name: Sik1 (SIK1 Products)

Synonyms: Msk antibody, Sik antibody, Snf1lk antibody, SIK2 antibody, SNF1LK antibody, MSK antibody, SIK antibody, salt-inducible kinase 1 antibody, salt inducible kinase 1 antibody, SIK1 antibody, Sik1 antibody

Background: Sik1 inhibits CREB binding and transcription of cAMP-responsive element (CRE)-dependent genes Cyp11A and Star.
Alias Symbols: Sik, Snf1lk
Protein Size: 776

Molecular Weight: 85 kDa

Gene ID: 59329

NCBI Accession: NM_021693, NP_067725

UniProt: Q9R1U5

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process