GM2A antibody (N-Term)

Catalog No. ABIN2782426

This Rabbit Polyclonal antibody specifically detects GM2A in WB. It exhibits reactivity toward Human and Guinea Pig.

Quick Overview for GM2A antibody (N-Term) (ABIN2782426)

Target: GM2A (GM2 Ganglioside Activator (GM2A))

Reactivity: Human, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GM2A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GM2A Antibody

Binding Specificity: N-Term

Purpose: GM2A Antibody - N-terminal region

Sequence: SWDNCDEGKD PAVIRSLTLE PDPIIVPGNV TLSVMGSTSV PLSSPLKVDL

Predicted Reactivity: Guinea Pig: 83%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against GM2A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GM2A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46007-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GM2A

Target: GM2A (GM2 Ganglioside Activator (GM2A))

Alternative Name: GM2A

Background:

Background Information: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.

Gene Name: GM2 ganglioside activator

Alternative Symbols: SAP-3, GM2-AP

Protein Name: Ganglioside GM2 activator

Molecular Weight: 21

Gene ID: 2760

NCBI Accession: NP_000396

UniProt: P17900