RRM2 antibody (N-Term)

Catalog No. ABIN2782440

Product Details anti-RRM2 Antibody

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Guinea Pig, Horse, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PALSGTRVLA SKTARRIFQE PTEPKTKAAA PGVEDEPLLR ENPRRFVIFP

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against RRM2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RRM2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 389 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-RRM2 antibody (ABIN2782440)

Lane, Yu, Lackey, Chen, Marzluff, Cook: "Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins." in: PLoS ONE, Vol. 8, Issue 3, pp. e58456, (2013) (PubMed).

Target Details for RRM2

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Alternative Name: RRM2 (RRM2 Products)

Synonyms: R2 antibody, RR2 antibody, RR2M antibody, AA407299 antibody, rrm2 antibody, rr2m antibody, cb111 antibody, chunp6884 antibody, r2 antibody, ribonucleotide reductase regulatory subunit M2 antibody, ribonucleotide reductase M2 antibody, ribonucleotide reductase M2, gene 2 L homeolog antibody, ribonucleotide reductase M2, gene 1 antibody, ribonucleotide reductase M2 polypeptide antibody, RRM2 antibody, Rrm2 antibody, rrm2.2.L antibody, rrm2.1 antibody, rrm2 antibody

Background: RRM2 provides the precursors necessary for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RRM2 inhibits Wnt signaling.Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, proteins M1 and M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: R2, RR2M, RR2
Protein Interaction Partner: DNM1L, UBC, gag-pol, RBMX, PCMT1, NONO, UBD, SKP2, NR1H4, RRM1, CCNF, ELAVL1, KAT5, RRM2B, CDH1, TP53, CDK1,
Protein Size: 389

Molecular Weight: 45 kDa

Gene ID: 6241

NCBI Accession: NM_001034, NP_001025

UniProt: P31350

Pathways: Mitotic G1-G1/S Phases