CRYZ antibody (Middle Region)

Catalog No. ABIN2782462

The Rabbit Polyclonal anti-CRYZ antibody is suitable to detect CRYZ in samples from Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Pig and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for CRYZ antibody (Middle Region) (ABIN2782462)

Target: CRYZ (Crystallin, zeta (CRYZ))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYZ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRYZ Antibody

Binding Specificity: Middle Region

Purpose: CRYZ Antibody - middle region

Sequence: KGIDIIIEML ANVNLSKDLS LLSHGGRVIV VGSRGTIEIN PRDTMAKESS

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 85%, Rat: 86%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against CRYZ. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CRYZ

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46065-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRYZ

Target: CRYZ (Crystallin, zeta (CRYZ))

Alternative Name: CRYZ

Background:

Background Information: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. CRYZ is a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low.Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. One pseudogene is known to exist.

Gene Name: Crystallin, zeta (quinone reductase)

Alternative Symbols: DKFZp779E0834, FLJ41475

Protein Name: Quinone oxidoreductase

Molecular Weight: 35kDa

Gene ID: 1429

NCBI Accession: NP_001880

UniProt: Q08257