CTH antibody (N-Term)

Catalog No. ABIN2782463

Product Details anti-CTH Antibody

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTH antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VPPISLSTTF KQGAPGQHSG FEYSRSGNPT RNCLEKAVAA LDGAKYCLAF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against CTH. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CTH

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 405 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-CTH antibody (ABIN2782463)

Perry, Kumai, Porteus, Tzaneva, Kwong: "An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish." in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, Vol. 186, Issue 2, pp. 145-59, (2016) (PubMed).

Kumai, Porteus, Kwong, Perry: "Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio." in: Pflügers Archiv : European journal of physiology, Vol. 467, Issue 4, pp. 651-64, (2015) (PubMed).

Porteus, Abdallah, Pollack, Kumai, Kwong, Yew, Milsom, Perry: "The role of hydrogen sulphide in the control of breathing in hypoxic zebrafish (Danio rerio)." in: The Journal of physiology, Vol. 592, Issue 14, pp. 3075-88, (2014) (PubMed).

Target Details for CTH

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Alternative Name: CTH (CTH Products)

Synonyms: DYT17 antibody, DYT18 antibody, DYT9 antibody, EIG12 antibody, GLUT antibody, GLUT1 antibody, GLUT1DS antibody, HTLVR antibody, PED antibody, wu:fb48e03 antibody, wu:fb58d08 antibody, zgc:66001 antibody, zgc:85785 antibody, CTH antibody, 0610010I13Rik antibody, AI314617 antibody, BC019483 antibody, CSE antibody, Cys3 antibody, cysA antibody, SCQ11.03c antibody, DDBDRAFT_0190313 antibody, DDBDRAFT_0191318 antibody, DDB_0190313 antibody, DDB_0191318 antibody, H antibody, MGC75946 antibody, cystathionine gamma-lyase antibody, solute carrier family 2 member 1 antibody, cystathionase (cystathionine gamma-lyase) antibody, cystathionine gamma-lyase L homeolog antibody, CTH antibody, SLC2A1 antibody, cth antibody, Cth antibody, SCO3920 antibody, mlr1566 antibody, TA_RS00415 antibody, MAP_RS15640 antibody, SPO3344 antibody, CNN01730 antibody, Mmcs_1928 antibody, RHA1_RS31820 antibody, HNE_1212 antibody, MAV_3867 antibody, MSMEG_2394 antibody, Mvan_2142 antibody, SACE_6136 antibody, Mflv_4220 antibody, cysA antibody, cth.L antibody

Background: CTH is a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in its gene cause cystathioninuria.This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Alias Symbols: MGC9471
Protein Interaction Partner: GUCD1, WDYHV1, RECK, CTH, PTMA, GMDS, CAPN2, ATIC, SDCBP2, UBC, ELAVL1,
Protein Size: 405

Molecular Weight: 44 kDa

Gene ID: 1491

NCBI Accession: NM_001902, NP_001893

UniProt: P32929

Pathways: ER-Nucleus Signaling, Warburg Effect