SMC4 antibody (N-Term)

Catalog No. ABIN2782504

The Rabbit Polyclonal anti-SMC4 antibody has been validated for WB. It is suitable to detect SMC4 in samples from Human, Mouse, Rat, Guinea Pig, Dog, Horse, Cow, Rabbit and Pig.

Quick Overview for SMC4 antibody (N-Term) (ABIN2782504)

Target: SMC4 (Structural Maintenance of Chromosomes 4 (SMC4))

Reactivity: Human, Mouse, Rat, Guinea Pig, Dog, Horse, Cow, Rabbit, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMC4 Antibody

Binding Specificity: N-Term

Sequence: SGRTESPATA AETASEELDN RSLEEILNSI PPPPPPAMTN EAGAPRLMIT

Predicted Reactivity: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SMC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1288 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMC4

Target: SMC4 (Structural Maintenance of Chromosomes 4 (SMC4))

Alternative Name: SMC4

Background: SMC4 is the central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Alias Symbols: CAPC, SMC4L1, hCAP-C, CAP-C, SMC-4
Protein Interaction Partner: UBC, SUMO2, LGR4, RPA3, RPA2, RPA1, RNF2, NCAPH, SMC2, SSSCA1, NCAPD2, TBC1D4, PLEC, AP3S1, CDK9, NCAPG, CCAR2, RABL6, TOPBP1, FBXO6, UBD, HDAC11, MYC, Nfe2l2, NEDD8, CDK2, SIRT7, NCAPH2, NCAPD3, RAD21, TRAF3IP1, SUMO1, HDAC1, tat, DNMT3B,
Protein Size: 1288

Molecular Weight: 147 kDa

Gene ID: 10051

NCBI Accession: NM_001002800, NP_001002800

UniProt: Q9NTJ3