PSME3 antibody (N-Term)

Catalog No. ABIN2782511

This Rabbit Polyclonal antibody specifically detects PSME3 in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse and Rabbit.

Quick Overview for PSME3 antibody (N-Term) (ABIN2782511)

Target: PSME3

Reactivity: Human, Rat, Mouse, Dog, Cow, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PSME3 Antibody

Binding Specificity: N-Term

Sequence: PILNIHDLTQ IHSDMNLPVP DPILLTNSHD GLDGPTYKKR RLDECEEAFQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PSME3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human PSME3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 267 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSME3

Target: PSME3

Alternative Name: PSME3

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME3 is the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring.
Alias Symbols: Ki, PA28-gamma, PA28G, REG-GAMMA
Protein Interaction Partner: SPG7, PRKAB2, PFDN5, BBS2, TNFAIP8L1, EAF1, ZCCHC10, PRR13, TXN2, FBXO7, DIP2A, PSME3, HUWE1, TUBGCP3, SIRT1, CREBBP, PSMD14, SHFM1, GTPBP4, MDM2, ADARB2, C1QBP, PARK2, CLK3, CLK2, YWHAQ, TBXA2R, BAG3, NPM1, ITGA4, CBX2, vpr, vif, HCVgp1, CBX4, VCAM1, UBC
Protein Size: 267

Molecular Weight: 31 kDa

Gene ID: 10197

NCBI Accession: NM_176863, NP_789839

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA