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PSME3 antibody (AA 2-252)

PSME3 Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7164919
  • Target See all PSME3 Antibodies
    PSME3
    Binding Specificity
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 2-252
    Reactivity
    • 40
    • 20
    • 15
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 37
    • 6
    Rabbit
    Clonality
    • 39
    • 4
    Polyclonal
    Conjugate
    • 28
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSME3 antibody is un-conjugated
    Application
    • 30
    • 13
    • 11
    • 7
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Proteasome activator complex subunit 3 protein (2-252AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    PSME3
    Alternative Name
    PSME3 (PSME3 Products)
    Synonyms
    AA410043 antibody, AU020960 antibody, Ki antibody, PA28gamma antibody, REGgamma antibody, pa28g antibody, Ab2-371 antibody, PA28-gamma antibody, PA28G antibody, REG-GAMMA antibody, psme3b antibody, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody, proteasome activator subunit 3 antibody, proteasome activator subunit 3 S homeolog antibody, Psme3 antibody, PSME3 antibody, psme3.S antibody
    Background

    Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

    Aliases: 11S regulator complex gamma subunit antibody, 11S regulator complex subunit gamma antibody, Activator of multicatalytic protease subunit 3 antibody, Ki antibody, Ki antigen antibody, Ki nuclear autoantigen antibody, Ki, PA28 gamma antibody, PA28 gamma antibody, PA28g antibody, PA28gamma antibody, Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody, Proteasome (prosome, macropain) activator subunit 3 antibody, Proteasome activator 28 gamma antibody, Proteasome activator 28 subunit gamma antibody, Proteasome activator complex subunit 3 antibody, Proteasome activator subunit 3 antibody, PSME3 antibody, PSME3_HUMAN antibody, REG GAMMA antibody, REG-gamma antibody

    UniProt
    P61289
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
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