SMC2 antibody (Middle Region)

Catalog No. ABIN2782520

The Rabbit Polyclonal anti-SMC2 antibody has been validated for WB. It is suitable to detect SMC2 in samples from Human, Rat, Mouse, Dog, Horse, Cow, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for SMC2 antibody (Middle Region) (ABIN2782520)

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Reactivity: Human, Rat, Mouse, Dog, Horse, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMC2 Antibody

Binding Specificity: Middle Region

Sequence: ATLAGQMMAC KNDISKAQTE AKQAQMKLKH AQQELKNKQA EVKKMDSGYR

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against SMC2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1197 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMC2

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Alternative Name: SMC2

Background: SMC2 belongs to the SMC family. It is a central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Alias Symbols: CAP-E, CAPE, FLJ10093, SMC2L1, hCAP-E
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, NCAPG, CCAR2, NCAPH, SSSCA1, SMC4, NCAPD2, PLEC, CDK9, FBXO6, EGFR, SOX2, GULP1, ABCC5, PAXIP1, SMC1A, UBD, NEDD8, SUMO2, NCAPG2, NCAPH2, NCAPD3, RAD21, LIG4, HIST2H3C, DISC1, TRAF3IP1, HIST2H2BE, HIST2H2AC, H2AFZ, MYC, tat, DNMT3B,
Protein Size: 1197

Molecular Weight: 136 kDa

Gene ID: 10592

NCBI Accession: NM_006444, NP_006435

UniProt: O95347