Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 (PDSS1) (Middle Region) antibody

Details for Product No. ABIN2782535
Target
Binding Specificity
Middle Region
4
1
1
1
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
6
5
4
3
3
3
3
3
2
2
2
1
1
1
Host
Rabbit
10
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
Application
Western Blotting (WB)
7
5
1
Options
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human PDSS1
Blocking Peptide Blocking peptide for this product available: ABIN981558
Sequence VIDDASSRRG KHTVNKIWGE KKAVLAGDLI LSAASIALAR IGNTTVISIL
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against PDSS1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Target
Alternative Name PDSS1 (PDSS1 Antibody Abstract)
Background PDSS1 is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. PDSS1 catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in PDSS1 gene are a cause of coenzyme Q10 deficiency.The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency.
Alias Symbols: COQ1, MGC70953, RP13-16H11.3, TPRT, TPT, hDPS1, DPS, SPS, TPT 1
Protein Interaction Partner: UBC,
Protein Size: 415
Molecular Weight 46 kDa
Gene ID 23590
NCBI Accession NM_014317, NP_055132
UniProt Q5T2R2
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 415 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images
Image no. 1 for anti-Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 1 (PDSS1) (Middle Region) antibody (ABIN2782535) WB Suggested Anti-PDSS1 Antibody Titration: 0.2-1 ug/ml Positive Control: Human heart