Oncostatin M Receptor antibody (Middle Region)

Catalog No. ABIN2782613

This anti-Oncostatin M Receptor antibody is a Rabbit Polyclonal antibody detecting Oncostatin M Receptor in WB. Suitable for Human, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for Oncostatin M Receptor antibody (Middle Region) (ABIN2782613)

Target: Oncostatin M Receptor (OSMR)

Reactivity: Human, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Oncostatin M Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Oncostatin M Receptor Antibody

Binding Specificity: Middle Region

Sequence: LLEKKTGYSQ ELAPSDNPHV LVDTLTSHSF TLSWKDYSTE SQPGFIQGYH

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 92%

Characteristics: This is a rabbit polyclonal antibody against OSMR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human OSMR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 979 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Oncostatin M Receptor

Target: Oncostatin M Receptor (OSMR)

Alternative Name: OSMR

Background: Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC150626, MGC150627, MGC75127, OSMRB, PLCA1
Protein Interaction Partner: UBC, CUL5, GAPDH, IL6ST, OSM, JAK2, JAK1, ERBB2,
Protein Size: 979

Molecular Weight: 110 kDa

Gene ID: 9180

NCBI Accession: NM_003999, NP_003990

UniProt: Q99650

Pathways: JAK-STAT Signaling, Growth Factor Binding