COX6A1 antibody (N-Term)

Catalog No. ABIN2782631

The Rabbit Polyclonal anti-COX6A1 antibody is suitable to detect COX6A1 in samples from Human. It has been validated for WB.

Quick Overview for COX6A1 antibody (N-Term) (ABIN2782631)

Target: COX6A1 (Cytochrome C Oxidase Subunit VIa Polypeptide 1 (COX6A1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX6A1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COX6A1 Antibody

Binding Specificity: N-Term

Purpose: COX6A1 Antibody - N-terminal region

Sequence: VVGVSSVSRL LGRSRPQLGR PMSSGAHGEE GSARMWKTLT FFVALPGVAV

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against COX6A1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46438-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for COX6A1

Target: COX6A1 (Cytochrome C Oxidase Subunit VIa Polypeptide 1 (COX6A1))

Alternative Name: COX6A1

Background:

Targeted Subunit: 6A1, mitochondrial

Background Information: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66 % amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented.

Gene Name: Cytochrome c oxidase subunit VIa polypeptide 1

Alternative Symbols: COX6A, CMTRID, COX6AL

Protein Name: Cytochrome c oxidase subunit 6A1, mitochondrial

Molecular Weight: 10kDa

Gene ID: 1337

NCBI Accession: NP_004364

UniProt: P12074