IL11RA antibody (Middle Region)

Catalog No. ABIN2782642

This anti-IL11RA antibody is a Rabbit Polyclonal antibody detecting IL11RA in WB. Suitable for Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit and Dog.

Quick Overview for IL11RA antibody (Middle Region) (ABIN2782642)

Target: IL11RA (Interleukin 11 Receptor, alpha (IL11RA))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL11RA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL11RA Antibody

Binding Specificity: Middle Region

Sequence: FLLKFRLQYR PAQHPAWSTV EPAGLEEVIT DAVAGLPHAV RVSARDFLDA

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against IL11RA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IL11RA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 422 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL11RA

Target: IL11RA (Interleukin 11 Receptor, alpha (IL11RA))

Alternative Name: IL11RA

Background: Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. IL11RA is the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain.Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
Alias Symbols: MGC2146, CRSDA
Protein Interaction Partner: IL11,
Protein Size: 422

Molecular Weight: 43 kDa

Gene ID: 3590

NCBI Accession: NM_004512, NP_004503

UniProt: Q14626

Pathways: JAK-STAT Signaling, Growth Factor Binding