MMP20 antibody (Middle Region)

Catalog No. ABIN2782654

Product Details anti-MMP20 Antibody

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Cow, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP20 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AAVYLREPQK TLFFVGDEYY SYDERKRKME KDYPKNTEEE FSGVNGQIDA

Predicted Reactivity: Cow: 93%, Dog: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against MMP20. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MMP20

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 483 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MMP20

Target: MMP20 (Matrix Metalloproteinase 20 (MMP20))

Alternative Name: MMP20 (MMP20 Products)

Synonyms: AI2A2 antibody, MMP-20 antibody, MMP25 antibody, MMP20 antibody, mmp20 antibody, matrix metallopeptidase 20 antibody, matrix metallopeptidase 20 L homeolog antibody, matrix metallopeptidase 20 (enamelysin) antibody, MMP20 antibody, mmp20.L antibody, Mmp20 antibody

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP20 degrades amelogenin, the major protein component of dental enamel matrix, and so the protein is thought to play a role in tooth enamel formation. A mutation in the gene encoding MMP20, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta.
Alias Symbols: AI2A2, MMP-20
Protein Interaction Partner: ACAN,
Protein Size: 483

Molecular Weight: 43 kDa

Gene ID: 9313

NCBI Accession: NM_004771, NP_004762

UniProt: O60882