ATP2A3 antibody (Middle Region)

Catalog No. ABIN2782669

This Rabbit Polyclonal antibody specifically detects ATP2A3 in WB. It exhibits reactivity toward Human, Rat, Cow, Dog, Guinea Pig, Horse and Rabbit.

Quick Overview for ATP2A3 antibody (Middle Region) (ABIN2782669)

Target: ATP2A3 (ATPase, Ca++ Transporting, Ubiquitous (ATP2A3))

Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP2A3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATP2A3 Antibody

Binding Specificity: Middle Region

Sequence: LISGWLFFRY LAIGVYVGLA TVAAATWWFV YDAEGPHINF YQLRNFLKCS

Predicted Reactivity: Cow: 79%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Rabbit: 77%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against ATP2A3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATP2A3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 999 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATP2A3

Target: ATP2A3 (ATPase, Ca++ Transporting, Ubiquitous (ATP2A3))

Alternative Name: ATP2A3

Background: ATP2A3 is one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction.This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: SERCA3
Protein Interaction Partner: BCL2, UBC, BMI1, HDAC11, env, ATF2, CDK2, TCF3, IRS1, WRAP73,
Protein Size: 999

Molecular Weight: 109 kDa

Gene ID: 489

NCBI Accession: NM_005173, NP_005164

UniProt: Q93084

Pathways: Myometrial Relaxation and Contraction, Ribonucleoside Biosynthetic Process