ALDH6A1 antibody (Middle Region)

Catalog No. ABIN2782682

The Rabbit Polyclonal anti-ALDH6A1 antibody has been validated for WB and IHC. It is suitable to detect ALDH6A1 in samples from Human, Mouse, Rat, Dog, Cow, Horse, Pig, Rabbit, Guinea Pig and Zebrafish (Danio rerio). There is 1 publication available.

Quick Overview for ALDH6A1 antibody (Middle Region) (ABIN2782682)

Target: ALDH6A1 (Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Pig, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH6A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ALDH6A1 Antibody

Binding Specificity: Middle Region

Sequence: GQVGVNVPIP VPLPMFSFTG SRSSFRGDTN FYGKQGIQFY TQLKTITSQW

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against ALDH6A1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ALDH6A1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 535 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ALDH6A1 antibody (ABIN2782682)

Kuiper, Williams, Distl, Drögemüller: "Assignment of the PAX6 gene to bovine chromosome 15q25-->q27 by fluorescence in situ hybridization and confirmation by radiation hybrid mapping." in: Cytogenetic and genome research, Vol. 109, Issue 4, pp. 533, (2005) (PubMed).

Target Details for ALDH6A1

Target: ALDH6A1 (Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1))

Alternative Name: ALDH6A1

Background: ALDH6A1 plays a role in valine and pyrimidine metabolism. ALDH6A1 binds fatty acyl-CoA. This protein belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. The product of this gene, a mitochondrial methylmalonate semialdehyde dehydrogenase, catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.
Alias Symbols: MGC40271, MMSADHA, MMSDH
Protein Interaction Partner: UBC, LMO2,
Protein Size: 535

Molecular Weight: 58 kDa

Gene ID: 4329

NCBI Accession: NM_005589, NP_005580

UniProt: Q02252

Pathways: Brown Fat Cell Differentiation