AFG3L2 antibody (Middle Region)

Catalog No. ABIN2782736

The Rabbit Polyclonal anti-AFG3L2 antibody has been validated for WB. It is suitable to detect AFG3L2 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Goat, Saccharomyces cerevisiae and Zebrafish (Danio rerio).

Quick Overview for AFG3L2 antibody (Middle Region) (ABIN2782736)

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Goat, Saccharomyces cerevisiae, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFG3L2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AFG3L2 Antibody

Binding Specificity: Middle Region

Sequence: VNFLKNPKQY QDLGAKIPKG AILTGPPGTG KTLLAKATAG EANVPFITVS

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 79%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against AFG3L2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AFG3L2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 797 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AFG3L2

Target: AFG3L2 (AFG3-Like Protein 2 (AFG3L2))

Alternative Name: AFG3L2

Background: AFG3L2 is a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. AFG3L2 gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
Alias Symbols: FLJ25993, SCA28
Protein Interaction Partner: SUMO2, UBC, SUZ12, RNF2, HIPK4, FBXO6, BTK, APP, MAPK8IP2, RAC2, ICT1, BECN1, CLN3, USP50, PHC2,
Protein Size: 797

Molecular Weight: 88 kDa

Gene ID: 10939

NCBI Accession: NM_006796, NP_006787

UniProt: Q9Y4W6

Pathways: Skeletal Muscle Fiber Development