PILRA antibody (N-Term)

Catalog No. ABIN2782793

The Rabbit Polyclonal anti-PILRA antibody is suitable to detect PILRA in samples from Human. It has been validated for WB.

Quick Overview for PILRA antibody (N-Term) (ABIN2782793)

Target: PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PILRA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PILRA Antibody

Binding Specificity: N-Term

Purpose: PILRA Antibody - N-terminal region

Sequence: IPFSFYYPWE LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN

Specificity: 100 % homologous to all four isoforms of human PILRA.

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PILRA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PILRA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46947-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PILRA

Target: PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))

Alternative Name: PILRA

Background:

Background Information: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

Gene Name: Paired immunoglobin-like type 2 receptor alpha

Alternative Symbols: FDF03

Protein Name: Paired immunoglobulin-like type 2 receptor alpha

Molecular Weight: 18kDa

Gene ID: 29992

NCBI Accession: NP_840057

UniProt: Q9UKJ1