ERVW-1 antibody (N-Term)

Catalog No. ABIN2782822

The Rabbit Polyclonal anti-ERVW-1 antibody (ABIN2782822) specifically detects ERVW-1 in WB. The antibody is reactive with Human and Rat samples.

Quick Overview for ERVW-1 antibody (N-Term) (ABIN2782822)

Target: ERVW-1 (Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERVW-1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ERVW-1 Antibody

Binding Specificity: N-Term

Purpose: ERVW-1 Antibody - N-terminal region

Sequence: CMTSSSPYQE FLWRMQRPGN IDAPSYRSLS KGTPTFTAHT HMPRNCYHSA

Predicted Reactivity: Human: 100%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against ERVW-1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ERVW-1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47044-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ERVW-1

Target: ERVW-1 (Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Alternative Name: ERVW-1

Background:

Background Information: ERVWE1 or syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene Name: endogenous retrovirus group W, member 1

Alternative Symbols: ENV, ENVW, HERVW, ERVWE1, HERV7Q, HERV-7q, HERVWENV, HERV-W-ENV

Protein Name: HERV-W_7q21.2 provirus ancestral Env polyprotein

Molecular Weight: 60 kDa

Gene ID: 30816

NCBI Accession: NP_055405

UniProt: Q9UQF0