HSD17B12 antibody (C-Term)

Catalog No. ABIN2782872

The Rabbit Polyclonal anti-HSD17B12 antibody is suitable to detect HSD17B12 in samples from Human, Rat, Mouse, Cow, Dog, Horse, Pig and Rabbit. It has been validated for WB.

Quick Overview for HSD17B12 antibody (C-Term) (ABIN2782872)

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HSD17B12 Antibody

Binding Specificity: C-Term

Purpose: Hsd17b12 Antibody - C-terminal region

Sequence: SAETFVKSAI KTVGLQTRTT GYVIHSLMGS INSIMPRWMY FKIIMGFSKS

Predicted Reactivity: Cow: 79%, Dog: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 79%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Hsd17b12. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Hsd17b12

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47217-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSD17B12

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Alternative Name: Hsd17b12

Background:

Background Information: Hsd17b12 catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in females. Hsd17b12 also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.

Alternative Symbols: KIK, Kik1, KIK-I, AI172963, 2610510O05Rik

Protein Name: Estradiol 17-beta-dehydrogenase 12

Molecular Weight: 35kDa

Gene ID: 56348

NCBI Accession: NP_062631

UniProt: O70503

Pathways: Steroid Hormone Biosynthesis