PCDH12 antibody (Middle Region)

Catalog No. ABIN2782896

This Rabbit Polyclonal antibody specifically detects PCDH12 in WB. It exhibits reactivity toward Rat, Human, Cow, Guinea Pig, Horse, Dog and Pig.

Quick Overview for PCDH12 antibody (Middle Region) (ABIN2782896)

Target: PCDH12 (Protocadherin 12 (PCDH12))

Reactivity: Rat, Human, Cow, Guinea Pig, Horse, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDH12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PCDH12 Antibody

Binding Specificity: Middle Region

Purpose: PCDH12 Antibody - middle region

Sequence: SSRPFLLTTI VARDADSGAN GEPLYSIRSG NEAHLFILNP HTGQLFVNVT

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 85%, Horse: 86%, Human: 100%, Pig: 92%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against PCDH12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PCDH12

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47275-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDH12

Target: PCDH12 (Protocadherin 12 (PCDH12))

Alternative Name: PCDH12

Background:

Background Information: PCDH12 belongs to the protocadherin protein family, a subfamily of the cadherin superfamily. It consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.

Gene Name: Protocadherin 12

Alternative Symbols: DMJDS1, VECAD2, VE-cadherin-2

Protein Name: Protocadherin-12

Molecular Weight: 126kDa

Gene ID: 51294

NCBI Accession: NP_057664

UniProt: Q9NPG4

Pathways: Cellular Glucan Metabolic Process