MGA (C-Term) antibody

Catalog No. ABIN2444597

The Rabbit Polyclonal anti-MGA antibody is suitable to detect MGA in samples from Human, Cow, Dog, Horse, Mouse, Pig, Rabbit and Rat. It has been validated for WB.

Quick Overview for MGA (C-Term) antibody (ABIN2444597)

Target: MGA

Reactivity: Human, Cow, Dog, Horse, Mouse, Pig, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: C-Term

Purpose: MGA Antibody - C-terminal region

Sequence: ASLQMKRESQ NPDQKDETNS IKREQETKKV LQSEGEAVDP EANVIKQNSG

Predicted Reactivity: Cow: 92%, Dog: 85%, Horse: 92%, Human: 100%, Mouse: 79%, Pig: 92%, Rabbit: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against MGA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MGA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47556-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: MGA

Background:

Background Information: MGA functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes and functions as a repressor or an activator. It binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. It suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. It function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor

Gene Name: MAX gene associated

Alternative Symbols: MAD5, MXD5

Protein Name: MAX gene-associated protein

Molecular Weight: 76kDa

Gene ID: 23269

UniProt: Q8IWI9