PSMC3IP antibody (Middle Region)

Catalog No. ABIN2783050

The Rabbit Polyclonal anti-PSMC3IP antibody (ABIN2783050) specifically detects PSMC3IP in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Goat and Guinea Pig samples.

Quick Overview for PSMC3IP antibody (Middle Region) (ABIN2783050)

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Goat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC3IP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PSMC3IP Antibody

Binding Specificity: Middle Region

Purpose: PSMC3IP Antibody - middle region

Sequence: RLKNIKAATN HVTPEEKEQV YRERQKYCKE WRKRKRMATE LSDAILEGYP

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against PSMC3IP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSMC3IP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8109623

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PSMC3IP

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Alternative Name: PSMC3IP

Background:

Background Information: PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.

Gene Name: PSMC3 interacting protein

Alternative Symbols: HOP2, ODG3, GT198, TBPIP, HUMGT198A

Protein Name: Homologous-pairing protein 2 homolog

Molecular Weight: 25kDa

Gene ID: 29893

NCBI Accession: NP_057640

UniProt: Q9P2W1