SETD2 antibody (N-Term)

Catalog No. ABIN2783051

This Rabbit Polyclonal antibody specifically detects SETD2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Horse and Cowand has been mentioned in 1 publication.

Quick Overview for SETD2 antibody (N-Term) (ABIN2783051)

Target: SETD2 (SET Domain Containing 2 (SETD2))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SETD2 Antibody

Binding Specificity: N-Term

Sequence: SDEDSVRTSS SQRSHDLKFS ASIEKERDFK KSSAPLKSED LGKPSRSKTD

Cross-Reactivity: Dog (Canine), Human, Rat (Rattus)

Predicted Reactivity: Cow: 79%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 83%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against SETD2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SETD2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 891 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SETD2 antibody (ABIN2783051)

Barrand, Andersen, Collas: "Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes." in: Biochemical and biophysical research communications, Vol. 401, Issue 4, pp. 611-7, (2010) (PubMed).

Target Details for SETD2

Target: SETD2 (SET Domain Containing 2 (SETD2))

Alternative Name: SETD2 / HIF1

Background: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SETD2 is a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs.
Alias Symbols: FLJ16420, FLJ22472, FLJ23184, FLJ45883, HIF-1, HSPC069, HYPB, KIAA1732, KMT3A, SET2, HIP-1, HBP231, p231HBP
Protein Interaction Partner: CLK2, SOX2, CBX8, HCVgp1, SIAH2, SMAD3, CIC, ATXN1, ELAVL1, UBC, SETD2, HIST1H3A, POLR2A, TP53, IWS1, HTT,
Protein Size: 891

Molecular Weight: 97 kDa

Gene ID: 29072

NCBI Accession: NM_014159

UniProt: Q9BYW2

Pathways: Tube Formation