ATRX antibody (C-Term)

Catalog No. ABIN2783135

The Rabbit Polyclonal anti-ATRX antibody (ABIN2783135) specifically detects ATRX in WB. The antibody is reactive with Human, Rabbit, Pig and Dog samples.

Quick Overview for ATRX antibody (C-Term) (ABIN2783135)

Target: ATRX (helicase 2, X-linked (ATRX))

Reactivity: Human, Rabbit, Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATRX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ATRX Antibody

Binding Specificity: C-Term

Purpose: ATRX Antibody - C-terminal region

Sequence: DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE

Predicted Reactivity: Dog: 88%, Human: 100%, Pig: 93%, Rabbit: 75%

Characteristics: This is a rabbit polyclonal antibody against ATRX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47775-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATRX

Target: ATRX (helicase 2, X-linked (ATRX))

Alternative Name: ATRX

Background:

Background Information: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene Name: similar to putative DNA dependent ATPase and helicase

Alternative Symbols: JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX

Protein Name: Transcriptional regulator ATRX

Molecular Weight: 148kDa

Gene ID: 546

UniProt: P46100