SGSH antibody (C-Term)

Catalog No. ABIN2783228

The Rabbit Polyclonal anti-SGSH antibody has been validated for WB. It is suitable to detect SGSH in samples from Human, Rat, Mouse, Cow, Horse and Dog.

Quick Overview for SGSH antibody (C-Term) (ABIN2783228)

Target: SGSH (N-Sulfoglucosamine Sulfohydrolase (SGSH))

Reactivity: Human, Rat, Mouse, Cow, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGSH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SGSH Antibody

Binding Specificity: C-Term

Sequence: ARWELYDRSR DPHETQNLAT DPRFAQLLEM LRDQLAKWQW ETHDPWVCAP

Predicted Reactivity: Cow: 79%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SGSH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human SGSH

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SGSH

Target: SGSH (N-Sulfoglucosamine Sulfohydrolase (SGSH))

Alternative Name: SGSH

Background: This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.
Alias Symbols: HSS, SFMD, MPS3A
Protein Size: 299

Molecular Weight: 32 kDa

Gene ID: 6448

NCBI Accession: NM_000199, NP_000190

UniProt: P51688

Pathways: Glycosaminoglycan Metabolic Process