SGSH antibody (N-Term)

Catalog No. ABIN2783227

The Rabbit Polyclonal anti-SGSH antibody (ABIN2783227) specifically detects SGSH in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Horse, Dog, Pig and Guinea Pig samples.

Quick Overview for SGSH antibody (N-Term) (ABIN2783227)

Target: SGSH (N-Sulfoglucosamine Sulfohydrolase (SGSH))

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Pig, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGSH antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SGSH Antibody

Binding Specificity: N-Term

Purpose: SGSH Antibody - N-terminal region

Sequence: RNALLLLADD GGFESGAYNN SAIATPHLDA LARRSLLFRN AFTSVSSCSP

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against SGSH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SGSH

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48123-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SGSH

Target: SGSH (N-Sulfoglucosamine Sulfohydrolase (SGSH))

Alternative Name: SGSH

Background:

Background Information: This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.

Gene Name: N-sulfoglucosamine sulfohydrolase

Alternative Symbols: HSS, SFMD, MPS3A

Protein Name: N-sulphoglucosamine sulphohydrolase

Molecular Weight: 57kDa

Gene ID: 6448

NCBI Accession: NP_000190

UniProt: P51688

Pathways: Glycosaminoglycan Metabolic Process