TPM2 antibody (C-Term)

Catalog No. ABIN2783288

Cited in 2+ publications. The Rabbit Polyclonal anti-TPM2 antibody (ABIN2783288) specifically detects TPM2 in WB and IHC. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse, Pig and Sheep samples.

Quick Overview for TPM2 antibody (C-Term) (ABIN2783288)

Target: TPM2 (Tropomyosin-2 (TPM2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse, Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TPM2 Antibody

Binding Specificity: C-Term

Purpose: TPM2 Antibody - C-terminal region

Sequence: AETRAEFAER SVAKLEKTID DLEDEVYAQK MKYKAISEEL DNALNDITSL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 100%, Rat: 100%, Sheep: 85%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against TPM2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TPM2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8114830

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-TPM2 antibody (ABIN2783288)

Abdul-Hussein, Rahl, Moslemi, Tajsharghi: "Phenotypes of myopathy-related beta-tropomyosin mutants in human and mouse tissue cultures." in: PLoS ONE, Vol. 8, Issue 9, pp. e72396, (2013) (PubMed).

Tajsharghi, Ohlsson, Lindberg, Oldfors: "Congenital myopathy with nemaline rods and cap structures caused by a mutation in the beta-tropomyosin gene (TPM2)." in: Archives of neurology, Vol. 64, Issue 9, pp. 1334-8, (2007) (PubMed).

Target Details for TPM2

Target: TPM2 (Tropomyosin-2 (TPM2))

Alternative Name: TPM2

Background:

Background Information: TPM2 is beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers.The TPM2 gene encodes beta-tropomyosin, an isoform of tropomyosin that is mainly expressed in slow, type 1 muscle fibers (Tajsharghi et al., 2007 [PubMed 17846275]). See also TPM1 (MIM 191010), TPM3 (MIM 191030), and TPM4 (MIM 600317).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Tropomyosin 2 (beta)

Alternative Symbols: DA1, DA2B, NEM4, TMSB, AMCD1, DA2B4, HEL-S-273

Protein Name: Tropomyosin beta chain

Molecular Weight: 33kDa

Gene ID: 7169

NCBI Accession: NP_003280

UniProt: P07951