Prohibitin 2 antibody (C-Term)

Catalog No. ABIN2783329

This Rabbit Polyclonal antibody specifically detects Prohibitin 2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog and Pig.

Quick Overview for Prohibitin 2 antibody (C-Term) (ABIN2783329)

Target: Prohibitin 2 (PHB2)

Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prohibitin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Prohibitin 2 Antibody

Binding Specificity: C-Term

Sequence: KLRKIRAAQN ISKTIATSQN RIYLTADNLV LNLQDESFTR GSDSLIKGKK

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PHB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PHB2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 299 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Prohibitin 2

Target: Prohibitin 2 (PHB2)

Alternative Name: PHB2

Background: PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It probably involved in regulating mitochondrial respiration activity and in aging.
Alias Symbols: BAP, BCAP37, Bap37, MGC117268, PNAS-141, REA, p22
Protein Interaction Partner: HUWE1, IGF1R, HDAC1, ESR1, KIAA1244, NCOR1, SUMO2, STAU1, UBC, MDM2, ASB14, ASB17, SUZ12, EED, RNF2, UPF2, ADRB2, CDK2, env, VCAM1, TEAD3, ITGA4, ILF3, FN1, ATF2, C1QBP, AFP, UBL4A, EPAS1, FMNL1, PAXIP1, MDC1, MYOD1, MEF2A, FHL2, ECT2, BRCA1, AKT1, Htt, U
Protein Size: 299

Molecular Weight: 33 kDa

Gene ID: 11331

NCBI Accession: NM_007273, NP_009204

UniProt: Q99623

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling