GMP Synthase antibody (Middle Region)

Catalog No. ABIN2783438

The Rabbit Polyclonal anti-GMP Synthase antibody is suitable to detect GMP Synthase in samples from Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Cow, Guinea Pig and Pig. It has been validated for WB.

Quick Overview for GMP Synthase antibody (Middle Region) (ABIN2783438)

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GMP Synthase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GMP Synthase Antibody

Binding Specificity: Middle Region

Purpose: GMPS Antibody - middle region

Sequence: VCTALLNRAL NQEQVIAVHI DNGFMRKRES QSVEEALKKL GIQVKVINAA

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against GMPS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GMPS

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48619-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for GMP Synthase

Target: GMP Synthase (GMPS) (Guanine Monophosphate Synthetase (GMPS))

Alternative Name: GMPS

Background:

Background Information: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.

Gene Name: Guanine monphosphate synthetase

Alternative Symbols: GATD7

Protein Name: GMP synthase [glutamine-hydrolyzing]

Molecular Weight: 77kDa

Gene ID: 8833

NCBI Accession: NP_003866

UniProt: P49915

Pathways: Ribonucleoside Biosynthetic Process