SULT1E1 antibody (Middle Region)

Catalog No. ABIN2783458

There are 2+ publications for this product available. The Rabbit Polyclonal anti-SULT1E1 antibody is suitable to detect SULT1E1 in samples from Human, Mouse, Rat, Dog, Horse, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for SULT1E1 antibody (Middle Region) (ABIN2783458)

Target: SULT1E1 (Sulfotransferase Family 1E Member 1 (SULT1E1))

Reactivity: Human, Mouse, Rat, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SULT1E1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SULT1E1 Antibody

Binding Specificity: Middle Region

Purpose: SULT1E1 Antibody - middle region

Sequence: LMVAGHPNPG SFPEFVEKFM QGQVPYGSWY KHVKSWWEKG KSPRVLFLFY

Predicted Reactivity: Dog: 85%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 83%, Rabbit: 92%, Rat: 83%

Characteristics: This is a rabbit polyclonal antibody against SULT1E1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SULT1E1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48669-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-SULT1E1 antibody (ABIN2783458)

Yalcin, Kulkarni, Slitt, King: "Bisphenol A sulfonation is impaired in metabolic and liver disease." in: Toxicology and applied pharmacology, Vol. 292, pp. 75-84, (2016) (PubMed).

Yalcin, More, Neira, Lu, Cherrington, Slitt, King: "Downregulation of sulfotransferase expression and activity in diseased human livers." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 41, Issue 9, pp. 1642-50, (2013) (PubMed).

Target Details for SULT1E1

Target: SULT1E1 (Sulfotransferase Family 1E Member 1 (SULT1E1))

Alternative Name: SULT1E1

Background:

Background Information: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.

Gene Name: Sulfotransferase family 1E, estrogen-preferring, member 1

Alternative Symbols: EST, STE, EST-1, ST1E1

Protein Name: Estrogen sulfotransferase

Molecular Weight: 35

Gene ID: 6783

NCBI Accession: NP_005411

UniProt: P49888

Pathways: Steroid Hormone Biosynthesis