QPCT antibody (Middle Region)

Catalog No. ABIN2783489

The Rabbit Polyclonal anti-QPCT antibody is suitable to detect QPCT in samples from Human, Mouse, Rat, Cow, Dog, Horse, Sheep, Guinea Pig and Rabbit. It has been validated for WB.

Quick Overview for QPCT antibody (Middle Region) (ABIN2783489)

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Sheep, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This QPCT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-QPCT Antibody

Binding Specificity: Middle Region

Sequence: SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 100%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against QPCT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human QPCT

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 361 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for QPCT

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Alternative Name: QPCT

Background: QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: GCT, QC, sQC
Protein Interaction Partner: CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, NEDD8, UBC,
Protein Size: 361

Molecular Weight: 38 kDa

Gene ID: 25797

NCBI Accession: NM_012413, NP_036545

UniProt: Q16769