BHMT2 antibody (Middle Region)

Catalog No. ABIN2783509

The Rabbit Polyclonal anti-BHMT2 antibody (ABIN2783509) specifically detects BHMT2 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Horse, Dog and Guinea Pig samples.

Quick Overview for BHMT2 antibody (Middle Region) (ABIN2783509)

Target: BHMT2 (Betaine--Homocysteine S-Methyltransferase 2 (BHMT2))

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BHMT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BHMT2 Antibody

Binding Specificity: Middle Region

Purpose: BHMT2 Antibody - middle region

Sequence: GFVDLPEYPF GLESRVATRW DIQKYAREAY NLGVRYIGGC CGFEPYHIRA

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 79%, Human: 100%, Mouse: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against BHMT2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BHMT2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48803-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for BHMT2

Target: BHMT2 (Betaine--Homocysteine S-Methyltransferase 2 (BHMT2))

Alternative Name: BHMT2

Background:

Background Information: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: Betaine--homocysteine S-methyltransferase 2

Alternative Symbols: FLJ20001

Protein Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2

Molecular Weight: 40kDa

Gene ID: 23743

NCBI Accession: NP_060084

UniProt: Q9H2M3

Pathways: Methionine Biosynthetic Process