NUDT15 antibody (N-Term)

Catalog No. ABIN2783521

The Rabbit Polyclonal anti-NUDT15 antibody (ABIN2783521) specifically detects NUDT15 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse and Saccharomyces cerevisiae samples.

Quick Overview for NUDT15 antibody (N-Term) (ABIN2783521)

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT15 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NUDT15 Antibody

Binding Specificity: N-Term

Purpose: Nudt15 Antibody - N-terminal region

Sequence: RKGSFGAGSF QLPGGHLEFG ETWEECAQRE TWEEAGLHLK NVCFASVVNS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against Nudt15. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48830-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NUDT15

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Alternative Name: Nudt15

Background:

Background Information: Nudt15 mediates the hydrolysis of some nucleoside diphosphate derivatives. It can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. Nudt15 may have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.

Gene Name: Nudix (nucleoside diphosphate linked moiety X)-type motif 15

Alternative Symbols: MTH2, 6530403O17, A730068G11Rik

Protein Name: Probable 8-oxo-dGTP diphosphatase NUDT15

Molecular Weight: 19kDa

Gene ID: 214254

NCBI Accession: NP_766115

UniProt: Q8BG93