NEK11 antibody (Middle Region)

Catalog No. ABIN2783561

The Rabbit Polyclonal anti-NEK11 antibody is suitable to detect NEK11 in samples from Human, Rat, Cow and Horse. It has been validated for WB.

Quick Overview for NEK11 antibody (Middle Region) (ABIN2783561)

Target: NEK11 (NIMA (Never In Mitosis Gene A)-Related Kinase 11 (NEK11))

Reactivity: Human, Rat, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEK11 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NEK11 Antibody

Binding Specificity: Middle Region

Purpose: NEK11 Antibody - middle region

Sequence: KEIRNEGSQP AYRTNQQDSD IEALARCLEN VLGCTSLDTK TITTMAEDMS

Predicted Reactivity: Cow: 77%, Horse: 100%, Human: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against NEK11. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human NEK11

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48920-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for NEK11

Target: NEK11 (NIMA (Never In Mitosis Gene A)-Related Kinase 11 (NEK11))

Alternative Name: NEK11

Background:

Background Information: NEK11 is a member of the never in mitosis gene A family of kinases. NEK11 localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. It appears to play roles in DNA replication and response to genotoxic stress. NEK11 belongs to the NIMA family of kinases, which are involved in DNA replication and genotoxic stress responses (Noguchi et al., 2002 [PubMed 12154088]).[supplied by OMIM]. Sequence Note: removed 2 bases from the 3' end that did not align to the reference genome assembly. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2937 AB071996.1 1-2937

Gene Name: NIMA (never in mitosis gene a)- related kinase 11

Alternative Symbols: FLJ23495

Protein Name: Serine/threonine-protein kinase Nek11

Molecular Weight: 74kDa

Gene ID: 79858

NCBI Accession: NP_079076

UniProt: Q8NG66