TGS1 antibody (Middle Region)

Catalog No. ABIN2783564

This Rabbit Polyclonal antibody specifically detects TGS1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Horse, Cow, Dog, Guinea Pig and Rabbit.

Quick Overview for TGS1 antibody (Middle Region) (ABIN2783564)

Target: TGS1 (Trimethylguanosine Synthase 1 (TGS1))

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGS1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TGS1 Antibody

Binding Specificity: Middle Region

Purpose: TGS1 Antibody - middle region

Sequence: IDENPASDFD DSGSLLGFKY GSGQKYGGIP NFSHRQVRYL EKNVKLKSKY

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 93%, Horse: 85%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against TGS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TGS1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48923-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TGS1

Target: TGS1 (Trimethylguanosine Synthase 1 (TGS1))

Alternative Name: TGS1

Background:

Background Information: TGS1 catalyzes the methylation step(s) for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. TGS1 plays a role in transcriptional regulation.

Gene Name: Trimethylguanosine synthase 1

Alternative Symbols: PIMT, PIPMT, NCOA6IP

Protein Name: Trimethylguanosine synthase

Molecular Weight: 96kDa

Gene ID: 96764

NCBI Accession: NP_079107

UniProt: Q96RS0

Pathways: Mitotic G1-G1/S Phases, Regulation of Lipid Metabolism by PPARalpha, Ribonucleoprotein Complex Subunit Organization