LTC4S antibody (N-Term)

Catalog No. ABIN2783616

There is 1 publication for this product available. The Rabbit Polyclonal anti-LTC4S antibody is suitable to detect LTC4S in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for LTC4S antibody (N-Term) (ABIN2783616)

Target: LTC4S (Leukotriene C4 Synthase (LTC4S))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTC4S antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LTC4S Antibody

Binding Specificity: N-Term

Purpose: LTC4S Antibody - N-terminal region

Sequence: MKDEVALLAA VTLLGVLLQA YFSLQVISAR RAFRVSPPLT TGPPEFERVY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 93%, Rat: 92%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against LTC4S. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LTC4S

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49035-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-LTC4S antibody (ABIN2783616)

Tang, Sally, Lesko, Discepolo, Abadie, Ciszewski, Semrad, Guandalini, Kupfer, Jabri: "Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease." in: The Journal of experimental medicine, Vol. 212, Issue 10, pp. 1487-95, (2015) (PubMed).

Target Details for LTC4S

Target: LTC4S (Leukotriene C4 Synthase (LTC4S))

Alternative Name: LTC4S

Background:

Background Information: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. LTC4S is an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma.The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Leukotriene C4 synthase

Alternative Symbols: MGC33147

Protein Name: Leukotriene C4 synthase

Molecular Weight: 16kDa

Gene ID: 4056

NCBI Accession: NP_665874

UniProt: Q16873

Pathways: Cellular Response to Molecule of Bacterial Origin