ALG1 antibody (C-Term)

Catalog No. ABIN2783688

This Rabbit Polyclonal antibody specifically detects ALG1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Dog and Guinea Pig.It has been mentioned in 1 publication

Quick Overview for ALG1 antibody (C-Term) (ABIN2783688)

Target: ALG1 (Chitobiosyldiphosphodolichol beta-Mannosyltransferase (ALG1))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALG1 Antibody

Binding Specificity: C-Term

Purpose: ALG1 Antibody - C-terminal region

Sequence: VKHEENGLVF EDSEELAAQL QMLFSNFPDP AGKLNQFRKN LRESQQLRWD

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 92%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against ALG1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human ALG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49252-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-ALG1 antibody (ABIN2783688)

Rind, Schmeiser, Thiel, Absmanner, Lübbehusen, Hocks, Apeshiotis, Wilichowski, Lehle, Körner: "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip." in: Human molecular genetics, Vol. 19, Issue 8, pp. 1413-24, (2010) (PubMed).

Target Details for ALG1

Target: ALG1 (Chitobiosyldiphosphodolichol beta-Mannosyltransferase (ALG1))

Alternative Name: ALG1

Background:

Background Information: The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik.

Gene Name: ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase

Alternative Symbols: HMT1, MT-1, CDG1K, HMAT1, HMT-1, Mat-1, hMat-1

Protein Name: chitobiosyldiphosphodolichol beta-mannosyltransferase

Molecular Weight: 38kDa

Gene ID: 56052

NCBI Accession: NP_061982

UniProt: B4DP08