PCDHGB1 antibody (N-Term)

Catalog No. ABIN2783725

This Rabbit Polyclonal antibody specifically detects PCDHGB1 in WB. It exhibits reactivity toward Human, Rabbit, Cow, Dog, Guinea Pig, Horse, Mouse, Rat and Zebrafish (Danio rerio).

Quick Overview for PCDHGB1 antibody (N-Term) (ABIN2783725)

Target: PCDHGB1 (Protocadherin gamma Subfamily B, 1 (PCDHGB1))

Reactivity: Human, Rabbit, Cow, Dog, Guinea Pig, Horse, Mouse, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PCDHGB1 Antibody

Binding Specificity: N-Term

Purpose: PCDHGB1 Antibody - N-terminal region

Sequence: SPDGSKYPVL LLEKPLDREH QSSHRLILTA MDGGDPPLSG TTHIWIRVTD

Predicted Reactivity: Cow: 85%, Dog: 92%, Guinea Pig: 90%, Horse: 83%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against PCDHGB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8109586

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHGB1

Target: PCDHGB1 (Protocadherin gamma Subfamily B, 1 (PCDHGB1))

Alternative Name: PCDHGB1

Background:

Background Information: PCDHGB1 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGB1 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Gene Name: Protocadherin gamma subfamily B, 1

Alternative Symbols: PCDH-GAMMA-B1

Protein Name: Protocadherin gamma-B1

Molecular Weight: 85kDa

Gene ID: 56104

NCBI Accession: NP_115266

UniProt: Q3SY75