PCDHB13 antibody (Middle Region)

Catalog No. ABIN503033

The Rabbit Polyclonal anti-PCDHB13 antibody is suitable to detect PCDHB13 in samples from Human. It has been validated for WB.

Quick Overview for PCDHB13 antibody (Middle Region) (ABIN503033)

Target: PCDHB13 (Protocadherin beta 13 (PCDHB13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHB13 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PCDHB13 Antibody

Binding Specificity: Middle Region

Purpose: PCDHB13 Antibody - middle region

Sequence: GKTFKINPLT GEIELKKQLD FEKLQSYEVN IEARDAGTFS GKCTVLIQVI

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PCDHB13. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PCDHB13

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49398-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PCDHB13

Target: PCDHB13 (Protocadherin beta 13 (PCDHB13))

Alternative Name: PCDHB13

Background:

Background Information: PCDHB13 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Gene Name: Protocadherin beta 13

Alternative Symbols: PCDH-BETA13

Protein Name: Protocadherin beta-13

Molecular Weight: 85kDa

Gene ID: 56123

NCBI Accession: NP_061756

UniProt: Q9Y5F0