LMBR1 antibody (N-Term)

Catalog No. ABIN2783870

The Rabbit Polyclonal anti-LMBR1 antibody is suitable to detect LMBR1 in samples from Human, Mouse, Rat, Cow, Rabbit and Dog. It has been validated for WB.

Quick Overview for LMBR1 antibody (N-Term) (ABIN2783870)

Target: LMBR1 (Limb Region 1 Homolog (LMBR1))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMBR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LMBR1 Antibody

Binding Specificity: N-Term

Purpose: LMBR1 Antibody - N-terminal region

Sequence: MEGQDEVSAR EQHFHSQVRE STICFLLFAI LYVVSYFIIT RYKRKSDEQE

Predicted Reactivity: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against LMBR1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LMBR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8104462

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for LMBR1

Target: LMBR1 (Limb Region 1 Homolog (LMBR1))

Alternative Name: LMBR1

Background:

Background Information: LMBR1 is a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of LMBR1 gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if LMBR1 gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression.This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Limb region 1 homolog (mouse)

Alternative Symbols: LSS, TPT, ZRS, ACHP, PPD2, THYP, DIF14, C7orf2

Protein Name: Limb region 1 protein homolog

Molecular Weight: 55kDa

Gene ID: 64327

NCBI Accession: NP_071903

UniProt: Q8WVP7