GNPTAB antibody (N-Term)

Catalog No. ABIN567223

This Rabbit Polyclonal antibody specifically detects GNPTAB in WB. It exhibits reactivity toward Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit, Rat and Zebrafish (Danio rerio).

Quick Overview for GNPTAB antibody (N-Term) (ABIN567223)

Target: GNPTAB (N-Acetylglucosamine-1-Phosphate Transferase, alpha and beta Subunits (GNPTAB))

Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNPTAB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GNPTAB Antibody

Binding Specificity: N-Term

Sequence: FQFGEVVLEW SRDQYHVLFD SYRDNIAGKS FQNRLCLPMP IDVVYTWVNG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against GNPTAB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GNPTAB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1256 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GNPTAB

Target: GNPTAB (N-Acetylglucosamine-1-Phosphate Transferase, alpha and beta Subunits (GNPTAB))

Alternative Name: GNPTAB

Background: This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.
Alias Symbols: DKFZp762B226, GNPTA, ICD, KIAA1208, MGC4170
Protein Interaction Partner: AEN, ZNF250, STAMBPL1, FAM90A1, PSMA1, MAPK1, APP, UBC, DISC1,
Protein Size: 1256

Molecular Weight: 143 kDa

Gene ID: 79158

NCBI Accession: NM_024312, NP_077288

UniProt: Q3T906