CYP2R1 antibody (Middle Region)

Catalog No. ABIN2783924

The Rabbit Polyclonal anti-CYP2R1 antibody is suitable to detect CYP2R1 in samples from Human, Mouse, Dog, Horse, Pig, Cow, Rabbit, Zebrafish (Danio rerio) and Guinea Pig. It has been validated for WB.

Quick Overview for CYP2R1 antibody (Middle Region) (ABIN2783924)

Target: CYP2R1 (Cytochrome P450, Family 2, Subfamily R, Polypeptide 1 (CYP2R1))

Reactivity: Human, Mouse, Dog, Horse, Pig, Cow, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2R1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYP2R1 Antibody

Binding Specificity: Middle Region

Sequence: FKQLITNAVS NITNLIIFGE RFTYEDTDFQ HMIELFSENV ELAASASVFL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against CYP2R1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CYP2R1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 501 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYP2R1

Target: CYP2R1 (Cytochrome P450, Family 2, Subfamily R, Polypeptide 1 (CYP2R1))

Alternative Name: CYP2R1

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
Alias Symbols: MGC4663
Protein Size: 501

Molecular Weight: 57 kDa

Gene ID: 120227

NCBI Accession: NM_024514, NP_078790

UniProt: Q6VVX0

Pathways: Metabolism of Steroid Hormones and Vitamin D