HSD3B7 antibody (Middle Region)

Catalog No. ABIN2783973

The Rabbit Polyclonal anti-HSD3B7 antibody (ABIN2783973) specifically detects HSD3B7 in WB. The antibody is reactive with Human, Mouse, Rat, Cow, Horse, Rabbit, Dog and Guinea Pig samples.

Quick Overview for HSD3B7 antibody (Middle Region) (ABIN2783973)

Target: HSD3B7 (Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 7 (HSD3B7))

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD3B7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HSD3B7 Antibody

Binding Specificity: Middle Region

Sequence: QGTRNVIEAC VQTGTRFLVY TSSMEVVGPN TKGHPFYRGN EDTPYEAVHR

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against HSD3B7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HSD3B7

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 369 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HSD3B7

Target: HSD3B7 (Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 7 (HSD3B7))

Alternative Name: HSD3B7

Background: This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PFIC4, CBAS1, SDR11E3
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-8, KRTAP10-1, KRTAP10-9, KRTAP4-2, SPRY2, UBC, KRTAP10-7, DAPP1, PYGL, ICAM1, Hoxa1,
Protein Size: 369

Molecular Weight: 41 kDa

Gene ID: 80270

NCBI Accession: NM_025193, NP_079469

UniProt: Q9H2F3