H13 antibody (Middle Region)

Catalog No. ABIN2783988

The Rabbit Polyclonal anti-H13 antibody is suitable to detect H13 in samples from Human, Mouse, Rabbit, Dog, Guinea Pig, Horse, Cow, Rat and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for H13 antibody (Middle Region) (ABIN2783988)

Target: H13 (Histocompatibility 13 (H13))

Reactivity: Human, Mouse, Rabbit, Dog, Guinea Pig, Horse, Cow, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H13 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-H13 Antibody

Binding Specificity: Middle Region

Purpose: H13 Antibody - middle region

Sequence: IKLVFPQDLL EKGLEADNFA MLGLGDIVIP GIFIALLLRF DISLKKNTHT

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against H13. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49964-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for H13

Target: H13 (Histocompatibility 13 (H13))

Alternative Name: H13

Background:

Background Information: H13 catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. It is required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 By similarity. It may play a role in graft rejection.

Gene Name: Histocompatibility 13

Alternative Symbols: Spp, H-13, Hm13, PSL3, AV020344, 1200006O09Rik, 4930443L17Rik, 5031424B04Rik

Protein Name: Minor histocompatibility antigen H13

Molecular Weight: 42kDa

Gene ID: 14950

NCBI Accession: NP_034506

UniProt: Q9D8V0