GTF2H2 antibody (N-Term)

Catalog No. ABIN2784198

The Rabbit Polyclonal anti-GTF2H2 antibody (ABIN2784198) specifically detects GTF2H2 in WB. The antibody is reactive with Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Dog, Cow, Rabbit and Guinea Pig samples.

Quick Overview for GTF2H2 antibody (N-Term) (ABIN2784198)

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Reactivity: Human, Mouse, Rat, Horse, Zebrafish (Danio rerio), Dog, Cow, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2H2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GTF2H2 Antibody

Binding Specificity: N-Term

Sequence: SLKATIEDIL FKAKRKRVFE HHGQVRLGMM RHLYVVVDGS RTMEDQDLKP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against Gtf2h2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of mouse GTF2H2

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GTF2H2

Target: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Alternative Name: Gtf2h2

Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene.
Alias Symbols: p44, BTF2, TFIIH, BTF2P44, T-BTF2P44
Protein Size: 201

Molecular Weight: 22 kDa

Gene ID: 2966

NCBI Accession: NM_001515, NP_001506

UniProt: Q13888

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling